ViiV Healthcare is looking for a Scientific Leader to join the Discovery DMPK (drug metabolism and pharmacokinetic) team based in Branford CT as a Project Specialist focused on discovering new medicines for the treatment, prevention and cure of HIV. As an individual contributor, the DMPK Project Specialist ensures that our DMPK science is embedded in Discovery projects across all modalities (small and large molecule) from commit to target through Phase I clinical work, and is accountable for driving the translational understanding of drug disposition and pharmacokinetic-pharmacodynamic (PKPD) approaches for projects that may include both oral and long-acting injectable medicines. The role requires working within matrix teams to design, complete and interpret in vitro and in vivo ADME studies, providing DMPK strategic leadership to discovery project teams, and contributing to the overall direction of our DMPK science to ensure that innovation is aligned with portfolio deliverables. Finally, the role has a significant writing component to contribute to internal reports, technical evidence, ADME reports and regulatory documents (e.g., IND, Investigator’s Brochure).

This role will provide the opportunity to lead key activities and to progress your career. These responsibilities include:

• Drive the DMPK strategy for multiple Drug Discovery stage projects from early lead optimization through Phase I clinical studies.
• Ensure that translational PKPD approaches and appropriate screening cascades with multi-parametric optimization are being applied to assigned projects.
• Utilize your extensive laboratory experience to design and conduct/oversee bespoke mechanism-based studies to address program needs.
• Efficiently manage your time and project requests for DMPK work to ensure optimal support of projects across different modalities in the ViiV Discovery pipeline.
• Coordinate and deliver high-quality DMPK written contributions to technical and regulatory documents.
• Develop and maintain excellent working relations with stakeholders in Discovery project teams, in order to ensure strategic alignment.
• Actively support cross-DMPK initiatives as a representative from the ViiV Nonclinical Safety and DMPK team to drive DMPK science and operations.

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• MS Degree (7 years’ experience) or PhD (>2 years’ experience post graducation) in a field relevant to DMPK (e.g., Pharmacology, Biochemistry, Pharmacokinetics or Drug Metabolism)
• Experience state-of-the-art DMPK science in projects to enable the discovery of new medicines, including experience with small molecules and biologics drug discovery and/or development.
• Experience managing DMPK related project resources and budgets.
• Experience working in cross-matrix teams, with demonstrated experience in project milestone delivery.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• PhD in a field relevant to DMPK (e.g., Pharmacology, Biochemistry, Pharmacokinetics or Drug Metabolism) with >5 years drug discovery experience.
• In-depth experience in DMPK representation in Discovery projects across different modalities (e.g., small molecule, mAb, long-acting injectable) and has strong experience in human dose prediction.
• Examples demonstrating the successful selection of drug candidates through efficient ADME screening cascades such as multi-parametric optimization, translational PKPD and human dose optimization strategies.
• Experience in leveraging modeling approaches and predictive science in Discovery projects to accelerate timelines and increase probability of success.
• Excellent communication/written skills and collaboration as demonstrated through publication and/or external interactions (e.g., university collaborations, speaking invitations etc.).

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Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program ViiV offers US employees. All ViiV employees receive the same benefits options and plans as GSK employee.

Why Us?

At ViiV Healthcare, we will not rest until we leave no person living with HIV behind. Until the 39 million people living with HIV is down to zero, we will continue searching for new ways to limit the impact of HIV.

We are the only pharmaceutical company solely focused on combating, preventing, and ultimately eradicating HIV and AIDS. At ViiV Healthcare, we do things differently. Born out of a partnership between GSK and Pfizer in 2009, with Shionogi joining in 2012, we are determined to help end the HIV epidemic. We are guided by our mission to leave no person living with HIV behind and it is this mission that unites our employees located across the globe. We combine expertise in research, manufacturing, policy and more to push the boundaries of what people think is possible in HIV treatment and care. As a result of our connection with GSK, we are able to draw on their proud history and resources. This means that you would receive all the employee benefits offered by GSK.

Living our mission of leaving no person living with HIV behind means keeping inclusion and diversity at the heart of everything we do - from our breakthrough innovation, to our diverse portfolio of medicines as well as the work we do to partner with HIV communities. Having a diverse team and a truly inclusive culture where we’re all able to be ourselves and feel like we belong will make us an even stronger team, better able to perform as a business and deliver on our mission to leave no person living with HIV behind.

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ViiV is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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