Job Description

Our Company's Research Laboratories in Boston are focused on driving discovery research. Our fully integrated multi-disciplinary discovery research site offers state-of-the-art resources to explore the most promising science combined with our Company's world-class R&D expertise in small molecules and biologics. Located within the heart of Boston's vibrant Longwood biomedical community, research conducted in our laboratories spans exploratory biology through early clinical development and is an integral part of our Company's powerful world-class network of drug and vaccine discovery.

At our Company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthroughs to impact the lives of patients, which relies on the integrity, creativity, humility, and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our Research & Development Division -Boston, you will expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career. We are seeking an enthusiastic and capable scientist to work as an integral part of our Boston Discovery Chemistry Separations Sciences Group. This hands-on laboratory role is responsible for the high-throughput purification of novel chemical compounds for drug discovery campaigns, troubleshooting and repairing chromatographic instrumentation, and performing purity analyses for biological assay submission. The candidate must demonstrate integrity and customer focus, strong collaborative and organizational skills, and flexibility and time management to support medicinal chemistry project needs.

Job Description

Primary responsibilities include purification of small molecules from reaction mixtures by applying standard LC/MS (Liquid Chromatography Mass spectroscopy) technologies, troubleshooting and basic repair of chromatographic instrumentation, SFC (Supercritical Fluid Chromatography) method development for chiral compounds for both enantiomeric excess (ee) determination and scaled up purification. In addition, the candidate will share and apply the best analytical chemistry and chromatography techniques to enable continuous improvement of the capabilities within the organization. This will involve driving the execution of compound purification in a high throughput automated environment. To achieve this, the candidate must have excellent skills in interacting and communicating with others, adapting to changing situations and managing their time, and a strong drive to help Medicinal Chemistry projects succeed.

Education Minimum Requirement:

• BS (Bachelor of Science) with a minimum of 3 years of industrial or academic experience in preparative chromatography and analytical chromatographic method development, or MS (Master of Science) degree in chemistry, biochemistry, or other physical science.

Required Experience:

• Understanding of analytical and separation chemistry and organic chemistry concepts

• Hands-on experience in the utilization, setup, and repair of HPLC (High-Performance Liquid Chromatography), LCMS (Liquid Chromatography Mass spectroscopy), and/or SFC (Supercritical Fluid Chromatography) instrumentation in an analytical/purification lab

• Knowledge of mass spectrometry and LCMS data interpretation

• Ability to multi-task and deliver on multiple priorities simultaneously

• Highly self-motivated, collaboration-oriented focus and attention to detail are critical to success in this position to support cross-functional teams across dynamic research programs

• Exceptional communication and organizational skills

Preferred Experience and Skills:

• Knowledge of HPLC and/or SFC purification of one or more of the following classes of chemical compounds: small molecules, peptides

• Knowledge of operation of laboratory automation instrumentation (e.g., automated balances, liquid handlers, automated chromatography)

• Experience in the development and analysis of chiral separations

• Knowledge of informatics and understanding of analytical software for data analysis

#EligibleforERP

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We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R326340